Desenvolvimento Vascular

Interesse da Investigação

The group research pursues a range of studies related to the signaling mechanisms regulating vascular development. We aim to better understand the molecular bases underlying cell-cell communication, cell fate decision, adhesion and migration during normal blood vessel morphogenesis/angiogenesis and to gain insight into their post-natal roles and their relevance for cancer and other disease conditions associated with neovascularization.

Publicações

(Selected) Update March (2009).

Benedito, R., Trindade, A., Hirashima, M., Henrique, D., Lopes-da-Costa, L., Rossant, J., Gill, P.S., Duarte, A. (2008). Loss of Notch signalling induced by Delta-like 4 (Dll4) causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli BMC Dev Biol 8(1) :117-125

Koch, U., Fiorini, E., Benedito, R., Besseyrias, V., Gossler, K., Pierres, M., Manley, N.R., Duarte, A., MacDonald, R., Radtke, F. (2008). Delta-like 4 is the essential, non-redundant ligand for Notch 1 during thymic T cell lineage commitment J Exp Med 205(11) :2515-23

Tammela, T., Waltari, M., Wirzenius, M., Suchting, S., Schomber, T., Murtomäki, A., Hellström, M., Haiko, P., Duarte, A., Ylä-Herttuala, S.Gerhard Christofori, G., Laakkonen , P., Betsholtz, C., Eichmann, A. and Alitalo, K. (2008). Inhibition of VEGFR-3 signaling suppresses angiogenic sprouting and vascular network formation Nature 454(7204) :656-60

Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte, A, Eichmann A. (2007). Negative regulators of vessel patterning Novartis Found Symp 283 :77-80

Schenet, J.S., Jiang, W., Kumar, S.R., Krasnoperov, V., Trindade, A., Benedito, R., Djokovic, D., Borges, C., Ley, E.J, Duarte, A. and Gill, P.S. (2007). Inhibition of Dll4 mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion Blood 109(11) :4753-60

Suchting, S., Freitas, C., le Noble, F., Benedito, R., Breant, C., Duarte, A., Eichmann, A. (2007). The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching Proceedings of the National Academy of Science USA 104(9) :3225-30

Seo S, Fujita H, Nakano A, Kang M, Duarte A, Kume T. (2006). The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development Dev Biol 294(2) :458-70

Benedito, R. & Duarte, A. (2005). Expression of Dll4 during mouse development suggests multiple developmental roles Gene Expression Patterns 5 :750-5

Duarte, A, Hirashima, M., Benedito, R., Trindade, A., Diniz, P., Lopes da Costa, L., Henrique, D. & Rossant, J. (2004). Dosage sensitive requirement for mouse Dll4 in artery development Genes & Development 18 :2472 - 2478