Stress & Transcrição

Interesse da Investigação

Signaling, Cell fate decision and apoptosis, Immune responses of the brain.

Membros do Grupo

Projecto de Investigação

Microglia activation and neuropathogenesis of cerebral malaria (CM).

We are addressing the signaling mechanisms in activated microglia by infection (extracts of parasitized erythrocytes) and dying neurons adopting a molecular approach to identify secreted entities like cytokines, intracellular signaling cascades and mechanisms of transcriptional regulation. This may elucidate the crux of the balance between cytotoxic and protective role of microglia in CM.

Projecto de Investigação

Molecular mechanisms of microtubule mediated signalling under oxidative stress.

This project focuses on analysis of the mechanism of signal transduction in G2/M block mediated apoptosis by concentrating on the role of a number of proteins involved in the stress pathway and mechanism leading to apoptosis.

Publicações

Chatterjee, S., Zama, K., Ryu, H., Conforto, A., Ratan, R.R. (2001). The sequence-selective DNA binding drugs, mithramycin and chomomycin are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons Anal. of Neurology 49 :345-354

Habib, A.A., Chatterjee, S. (2001). The epidermal growth factor receptor engages RIP (receptor interacting protein) and NIK(NF-kB inducing kinase) to activate NF-kB: Identification of a novel RTK signalosome J. Biol. Chem 12 :8865-8874

Hognason, T, Chatterjee, S., Vartanian, T., Ratan, R., Ernewein M, and Habib, A.A. (2001). Epidermal growth factor receptor induced apoptosis: Potentiation by inhibition of Rassignaling FEBS Letters 491 :9-15

Marone, M; D'Andrilli, G., Das, N., Ferlini, C.; Scambia, G Chatterjee, S (2001). Quercetin abrogates taxol-mediated signaling by inhibiting multiple kinases Experimental Cell Research 270 :1-12

Chatterjee, S., Lee, M., Struhl, K. (2000). Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup 1 corepressor Genetics 155 :1535-1542