Desenvolvimento e Simetria

Interesse da Investigação

Our group is studying the molecular mechanisms that control asymmetric versus symmetric development, using the chick and the zebrafish embryos as model organisms. During embryonic development it is important to create left-right asymmetry in the lateral plate mesoderm to allow the correct positioning of the internal organs. In addition, it is fundamental to maintain symmetry between the left and the right sides of the presomitic mesoderm to ensure the perfect allocation of symmetric body structures such as the axial skeleton, skeletal muscles and peripheral nerves.

Publicações

Saúde, L., Lourenço, R., Gonçalves, A. and Palmeirim, I. (2005). terra is a left-right asymmetry gene required for left-right synchronization of the segmentation clock Nature Cell Biology 7(9) :918-20

Freitas, C., Rodrigues S., Saúde, L. and Palmeirim, I. (2005). Running after the clock The International Journal of Developmental Biology 49(2-3) :317-2

Coutinho, P., Parsons, M. J., Thomas, K. A., 1, Hirst, E. M. A., Saúde, L., Campos, I., Williams, P. H. and Stemple, D. L. (2004). Differential requirements for COPI transport during vertebrate early development. Developmental Cell 7(4) :547-58

Feldman, B., Concha M. L., Saúde, L., Parsons, M. J., Adams, R. J., Wilson, S. W. and Stemple, D. L. (2002). Lefty antagonism of Squint is essential for normal gastrulation. Current Biology 12 (24) :2129-35

Parsons, M. J., Pollard, S. M., Saúde, L., Feldman, B., Coutinho, P., Hirst, E. M. and Stemple, D. L. (2002). Zebrafish mutants identify an essential role for laminins in notochord formation Development 129(13) :3137-46

Saúde, L., Woolley, K., Martin, P., Driever, W. and Stemple, D. L. (2000). Axis-inducing activities and cell fates of the zebrafish organizer. Development 127(16) :3407-17

Heisenberg, C-P., Tada, M., Rauch, G-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C. and Wilson, S. W. (2000). Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature 405 :(6782)76-81